反応 #50816

反応方程式

sodium bicarbonate

5-(p-carboxyphenyl)imidazo[1,5-a]pyridine

oxalyl chloride

tert-butylamine

→

title compound

5-(p-tert-Butylaminocarbonylphenyl)imidazo[1,5-a]pyridine

溶媒

methylene chloride

N,N-dimethylformamide

反応条件

後処理

1. 1
   workup.STIRRINGStirring
2. 2
   その他The organic layer is separated
3. 3
   乾燥dried over sodium sulfate
4. 4
   その他evaporated

実験手順

To a slurry of 0.4 g of 5-(p-carboxyphenyl)imidazo[1,5-a]pyridine in 40 ml of methylene chloride under nitrogen at room temperature, is added 30 μl of N,N-dimethylformamide followed by 0.16 ml of oxalyl chloride. The reaction mixture is stirred until gas evolution is complete and 0.46 ml of tert-butylamine is added dropwise. Stirring is discontinued after 90 min and 10 ml of saturated sodium bicarbonate solution is added. The organic layer is separated, dried over sodium sulfate and evaporated to yield the title compound, m.p. 128°-131°.

出典