反応 #50810

反応方程式

5-(3-chloropropyl)-1-(p-cyanophenylmethyl)-1H-imidazole

potassium t-butoxide

acetic acid

→

title compound

5-(p-Cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyridine hydrochloride

溶媒

tetrahydrofuran

acetone

hydrogen chloride

反応条件

後処理

1. 1
   その他partitioned between methylene chloride and water
2. 2
   洗浄The organic layer is washed with water
3. 3
   乾燥dried over magnesium sulfate
4. 4
   その他evaporated
5. 5
   その他to yield an oil which
6. 6
   温度On cooling

実験手順

A solution of 8.1 g of 5-(3-chloropropyl)-1-(p-cyanophenylmethyl)-1H-imidazole in 50 ml of tetrahydrofuran is cooled to 0°. To this is added 7.0 g of potassium t-butoxide as a solid in portions. The mixture is stirred at room temperature for 2 h, neutralized with 10% acetic acid and partitioned between methylene chloride and water. The organic layer is washed with water, dried over magnesium sulfate and evaporated to yield an oil which is dissolved in a small volume of acetone and neutralized with ethereal hydrogen chloride. On cooling, the title compound is obtained as a white solid, m.p. 201°-203°.

出典