反応 #50759

反応方程式

2,5-Dimethoxytetrahydrofuran

benzenesulphinic acid

calcium chloride

→

2-benzenesulphonyl-5-methoxytetrahydro-furan

収率 55.0%

溶媒

DCM

反応条件

後処理

1. 1
   workup.ADDITIONcontaining
2. 2
   洗浄the solution was washed with water (2×50 ml)
3. 3
   乾燥dried over anhydrous sodium sulphate
4. 4
   ろ過filtered
5. 5
   その他evaporated
6. 6
   その他The product was crystalised (diethyl ether/hexane)

実験手順

2,5-Dimethoxytetrahydrofuran (17.1 ml, 0.13M) was added dropwise to a stirred solution of benzenesulphinic acid (17.0 g, 0.12M) in dry DCM (100 ml) containing a suspension of powdered calcium chloride (1.0 g) at room temperature under argon. After 4 h, the solution was washed with water (2×50 ml), dried over anhydrous sodium sulphate, filtered and evaporated. The product was crystalised (diethyl ether/hexane) to give 2-benzenesulphonyl-5-methoxytetrahydro-furan as a white crystalline solid (15.9 g, 55%).

出典