反応 #50705

反応方程式

KOH

nitrile

1-(benzoyloxymethyl)cyclopropaneacetonitrile

diazomethane

Et2O

→

title compound

収率 50.0%

Methyl 1-(hydroxymethyl)cyclopropaneacetate

収率 50.0%

溶媒

ethanol

hexane

反応条件

後処理

1. 1
   温度the reaction mixture was heated
2. 2
   温度to reflux overnight
3. 3
   その他Most of the ethanol was evaporated
4. 4
   workup.ADDITIONice was added to the mixture
5. 5
   workup.ADDITIONConcentrated HCl was added (600 mL) dropwise at 0° C. (
6. 6
   抽出The acid was then extracted with EtOAc two times
7. 7
   洗浄the organic phases were washed 2 times with brine
8. 8
   乾燥dried over Na2SO4
9. 9
   その他The solvent was evaporated
10. 10
    workup.DISSOLUTIONthe solid was dissolved in THF (500 mL)
11. 11
    その他The solvent was evaporated
12. 12
    その他the residual oil was purified by flash chromatography

実験手順

The nitrile of Step 3 (0.388 mol) was dissolved in ethanol (400 mL), 8N KOH (800 mL) was added and the reaction mixture was heated to reflux overnight. Most of the ethanol was evaporated and ice was added to the mixture. Concentrated HCl was added (600 mL) dropwise at 0° C. (without warming over 10° C. inside the solution) until obtention of pH approx. 1. The acid was then extracted with EtOAc two times and the organic phases were washed 2 times with brine and dried over Na2SO4. The solvent was evaporated and the solid was dissolved in THF (500 mL). A solution of diazomethane in Et2O (about 1.7 L, 0.85 mol) was added at 0° C. until the yellow color remained and no more acid could be seen by TLC. The solvent was evaporated and the residual oil was purified by flash chromatography using 1:1 to 2:1 EtOAc:hexane to yield 28.2 g, (50% yield) of the title compound. 1H NMR (CDCl3) δ0.55 (4H, m), 2.45 (2H, s), 2.55 (1H, t), 3.5 (2H, d), 3.70 (3H, s).

出典