反応 #5070

反応方程式

Potassium fluoride

Methyl 3-iodobenzoate

vinyl tributyltin

→

Methyl 3-ethylbenzoate

溶媒

water

toluene

ethyl acetate

反応条件

後処理

1. 1
   温度The solution was heated
2. 2
   温度at reflux
3. 3
   workup.STIRRINGto stir under N2 for 15 minutes
4. 4
   洗浄washed with water
5. 5
   抽出The organic extract
6. 6
   乾燥was dried (MgSO4)
7. 7
   その他evaporated in vacuo

実験手順

Methyl 3-iodobenzoate (13 g) and vinyl tributyltin (20 g) were dissolved in toluene (100 ml) and tetrakis(triphenylphosphine)palladium (0) (500 mg) added. The solution was heated at reflux with stirring under N2 for 1 day. Potassium fluoride (3 g) in water (50 ml) was added and the reaction mixture was allowed to stir under N2 for 15 minutes. The product was taken up in ethyl acetate and washed with water and then brine (×2). The organic extract was dried (MgSO4) and evaporated in vacuo.

出典