反応 #50695

反応方程式

sodium

Diethyl malonate

sodium ethoxide

Isoamyl bromide

→

Sodium ethoxide

diethyl isoamylmalonate

溶媒

ethanol

ethanol

反応条件

後処理

1. 1
   温度the reaction mixture was heated
2. 2
   温度under reflux overnight
3. 3
   workup.DISTILLATIONAfter the usual work-up, the resulting crude product was distilled under reduced pressure

実験手順

Sodium ethoxide was prepared from sodium metal (9.1 g) and freshly distilled absolute ethanol (250 ml). Diethyl malonate (63.5 g) was added to sodium ethoxide in ethanol, and the mixture was stirred at 60°-70° C. for 50 min. Isoamyl bromide (60 g) was added, and the reaction mixture was heated under reflux overnight. After the usual work-up, the resulting crude product was distilled under reduced pressure to give diethyl isoamylmalonate. Yield: 71.7 g (78%).

出典