反応 #5067

反応方程式

1-benzylpiperid-4-one

butyllithium

5-bromo-1,4-benzodioxane

water

→

1-Benzyl-4-hydroxy-4-(1,4-benzodioxan-5-yl)piperidine

溶媒

tetrahydrofuran

hexane

tetrahydrofuran

反応条件

後処理

1. 1
   workup.ADDITIONWhen the addition
2. 2
   workup.STIRRINGThe mixture is stirred for 2 hours at -40° C.
3. 3
   workup.WAITfor 2 hours at ambient temperature before hydrolyzing using

実験手順

23.3 ml of a 1.6M solution of butyllithium in hexane are added dropwise to a solution, previously cooled to -60° C., of 8 g of 5-bromo-1,4-benzodioxane in 400 ml of tetrahydrofuran. When the addition is complete, the mixture is stirred at -60° C. for 5 minutes and a solution of 8 g of 1-benzylpiperid-4-one in 100 ml of tetrahydrofuran is then added dropwise. The mixture is stirred for 2 hours at -40° C. and then for 2 hours at ambient temperature before hydrolyzing using 80 ml of water.

出典