反応 #50631

反応方程式

Fumarate

8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

1-(2-pyridinyl)piperazine

chloroform

→

2,3-dihydro-7-methoxy-8-{3-[4-(2-pyridinyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one

収率 68.0%

溶媒

ethanol

acetone

反応条件

後処理

1. 1
   その他Method B (75 h at 45° C.)

実験手順

Method B (75 h at 45° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(2-pyridinyl)piperazine; yield 68%; fusion point 152°-154° C. (from chloroform and ethanol). Fumarate: method E; yield 96%; fusion point 205°-207° C. (from acetone).

出典