反応 #50628

反応方程式

Fumarate

8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one

1-(2-ethoxyphenyl)piperazine hydrochloride

isopropanol

→

8-{3-[4-(2-ethoxyphenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

収率 72.0%

溶媒

acetone

反応条件

後処理

1. 1
   その他Method B (40 h at 50° C.)

実験手順

Method B (40 h at 50° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(2-ethoxyphenyl)piperazine hydrochloride; yield 72%; fusion point 169°-170° C. (from isopropanol). Fumarate: method E; yield 85%; fusion point 159°-161° C. (from acetone).

出典