反応 #50627

反応方程式

Fumarate

8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

1-(4-methoxyphenyl)piperazine dihydrochloride

ethanol

→

2,3-dihydro-7-methoxy-8-{3-[4-(4-methoxyphenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one

収率 45.0%

溶媒

acetone

反応条件

後処理

1. 1
   その他Method A (60 h at 40° C.)

実験手順

Method A (60 h at 40° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(4-methoxyphenyl)piperazine dihydrochloride; yield 45%; fusion point 155°-156° C. (from ethanol). Fumarate: method E; yield 96%; fusion point 207°-210° C. (from acetone).

出典