反応 #50626

反応方程式

Fumarate

8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

1-(3-methoxyphenyl)piperazine

ethanol

→

2,3-dihydro-7-methoxy-8-{3-[4-(3-methoxyphenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one

収率 58.0%

溶媒

isopropanol

acetone

反応条件

後処理

1. 1
   その他Method B (60 h at 50° C.)

実験手順

Method B (60 h at 50° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(3-methoxyphenyl)piperazine; yield 58%; fusion point 130°-132° C. (from ethanol and isopropanol). Fumarate: method E; yield 80%; fusion point 174°-175° C. (from acetone).

出典