反応 #50625

反応方程式

Fumarate

8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

1-(2-methoxyphenyl)piperazine hydrochloride

chloroform

→

2,3-dihydro-7-methoxy-8-{3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one

収率 56.0%

溶媒

ethanol

acetone

反応条件

後処理

1. 1
   その他Method A (40 h at 50° C.)

実験手順

Method A (40 h at 50° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(2-methoxyphenyl)piperazine hydrochloride; yield 56%; fusion point 177°-178° C. (from chloroform and ethanol). Fumarate: method E; yield 87%; fusion point 173°-174° C. (from acetone).

出典