反応 #5061

反応方程式

hydrogen chloride

compound

4-(naphth-1-yl)piperidine hydrobromide

potassium carbonate

bromoacetonitrile

→

hydrochloride

収率 91.8%

(4-Naphth-1-ylpiperid-1-yl)acetonitrile hydrochloride

収率 91.8%

溶媒

acetone

反応条件

後処理

1. 1
   温度under reflux
2. 2
   ろ過After filtering
3. 3
   その他evaporation of the filtrate
4. 4
   その他the residue obtained

実験手順

5 g of the compound from Example 3, 7.088 g of potassium carbonate and 2.259 g of bromoacetonitrile in 200 ml of acetone are stirred for 10 hours under reflux and a stream of nitrogen. After filtering and evaporation of the filtrate, the residue obtained is treated with an ethanolic solution of hydrogen chloride to give 4.5 g of the expected hydrochloride.

出典