反応 #50602

反応方程式

Fumarate

6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-methyl-2H-1-benzopyran-2-one

1-phenylpiperazine

isopropanol

→

7-methoxy-4-methyl-6-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one

収率 77.0%

溶媒

acetone

ethanol

ethanol

反応条件

後処理

1. 1
   その他Method B (32 h at 50° C.)

実験手順

Method B (32 h at 50° C.); starting materials: 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-methyl-2H-1-benzopyran-2-one (example 74) and 1-phenylpiperazine; yield 77%; fusion point 137°-140° C. (from isopropanol and ethanol). Fumarate: method E; yield 79%; fusion point 195°-200° C. (from ethanol and acetone).

出典