反応 #50601

反応方程式

Hydrochloride

7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one

4-[bis(4-fluorophenyl)hydroxymethyl]piperidine

methanol

→

(±)-6-{3-[4-(bis(4-fluorophenyl)hydroxymethyl)-1-piperidinyl]-2-hydroxypropoxy}-7-methoxy-2H-1-benzopyran-2-one

収率 45.0%

溶媒

ethanol

isopropanol

chloroform

反応条件

後処理

1. 1
   その他Method C (5 d at 45° C.)

実験手順

Method C (5 d at 45° C.); starting materials: 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one and 4-[bis(4-fluorophenyl)hydroxymethyl]piperidine; yield 45%; fusion point 220°-221° C. (from methanol and chloroform). Hydrochloride: method G; yield 99%; fusion point 172°-174° C. (from isopropanol and ethanol).

出典