反応 #50600

反応方程式

7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one

4-hydroxy-4-phenylpiperidine

Hydrochloride

→

(±)-6-[2-hydroxy-3-(4-hydroxy-4-phenyl-1-piperidinyl)propoxy]-7-methoxy-2H-1-benzopyran-2-one

収率 69.0%

溶媒

isopropanol

isopropanol

反応条件

後処理

1. 1
   その他Method C (3 d at 40° C.)

実験手順

Method C (3 d at 40° C.); starting materials: 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one and 4-hydroxy-4-phenylpiperidine; yield 69%; fusion point 155°-157° C. (from isopropanol). Hydrochloride: method G; yield 88%; fusion point 202°-203° C. (from isopropanol).

出典