反応 #50598

反応方程式

Hydrochloride

6-methoxy-7-(oxiranylmethoxy)-2H-1-benzopyran-2-one

1-(3-trifluoromethylphenyl)piperazine

methanol

→

(±)-7-{2-hydroxy-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propoxy}-6-methoxy-2H-1-benzopyran-2-one

収率 80.0%

溶媒

isopropanol

反応条件

後処理

1. 1
   その他Method C (1.5 d at 45° C.)

実験手順

Method C (1.5 d at 45° C.); starting materials: 6-methoxy-7-(oxiranylmethoxy)-2H-1-benzopyran-2-one (example 86) and 1-(3-trifluoromethylphenyl)piperazine; yield 80%; fusion point 133°-135° C. (from methanol). Hydrochloride: method F; yield 83%; fusion point 125°-128° C. (decomposes; from isopropanol).

出典