反応 #505941

反応方程式

hexane ethyl acetate

2-(4-carboxybenzyl)-3-isopropylmaleic acid dimethyl ester

ammonia dioxane

4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

→

title compound

収率 91.3%

2-(4-Carbamoylbenzyl)-3-isopropylmaleic acid dimethyl ester

収率 91.3%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   濃縮The reaction mixture was directly concentrated under reduced pressure
2. 2
   その他the residue thus obtained

実験手順

To a solution of 2-(4-carboxybenzyl)-3-isopropylmaleic acid dimethyl ester (7.8 mg, 0.024 mmol) in tetrahydrofuran (400 μL) were added a 0.5 M ammonia-dioxane solution (600 μL) and 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (14.8 mg, 0.0535 mmol), and the mixture was stirred at room temperature for 4 h. The reaction mixture was directly concentrated under reduced pressure and the residue thus obtained was subjected to silica gel column chromatography (hexane-ethyl acetate 1:4) to give 7.0 mg of the title compound as a solid (yield: 90%).

出典