反応 #50589

反応方程式

Fumarate

6-(cyclo-pentyloxy)-7-[3-(methanesulfonyloxy)propoxy]-2H-1-benzopyran-2-one

1-phenylpiperazine

TBME

→

6-(cyclopentyloxy)-7-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one

収率 68.0%

溶媒

isopropanol

acetone

反応条件

後処理

1. 1
   その他Method B (25 h at 40° C.)

実験手順

Method B (25 h at 40° C.); starting materials: 6-(cyclo-pentyloxy)-7-[3-(methanesulfonyloxy)propoxy]-2H-1-benzopyran-2-one (example 72) and 1-phenylpiperazine; yield 68%; fusion point 101°-103° C. (from TBME and isopropanol). Fumarate: method E; yield 88%; fusion point 171°-173° C. (from acetone).

出典