反応 #50588

反応方程式

Fumarate

6-ethoxy-7-[3-(methanesulfonyloxy)-propoxy]-2H-1-benzopyran-2-one

1-phenylpiperazine

isopropanol

→

6-ethoxy-7-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one

収率 76.0%

溶媒

acetone

ethanol

反応条件

後処理

1. 1
   その他Method B (40 h at 50° C.)

実験手順

Method B (40 h at 50° C.); starting materials: 6-ethoxy-7-[3-(methanesulfonyloxy)-propoxy]-2H-1-benzopyran-2-one (see example 71) and 1-phenylpiperazine; yield 76%; fusion point 116° to 117° C. (from isopropanol). Fumarate: method E; yield 94%; fusion point 185° to 187° C. (from ethanol and acetone).

出典