反応 #50586

反応方程式

3-(chloropropoxy)-6-methoxy-2H-1-benzopyran-2-one

1-phenylpiperazine

Fumarate

→

6-methoxy-7-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one

収率 94.0%

溶媒

TBME

isopropanol

TBME

isopropanol

反応条件

後処理

1. 1
   その他Method B (9 h at 70° C.)

実験手順

Method B (9 h at 70° C.); starting materials: 7-[3-(chloropropoxy)-6-methoxy-2H-1-benzopyran-2-one (see example 69) and 1-phenylpiperazine; yield 94%; fusion point 82° to 83° (from isopropanol and TBME). Fumarate: method E; yield 94%; fusion point 168° to 170° C. (from isopropanol and TBME).

出典