反応 #50522

反応方程式

1,5-dimethyl-4-hydroxymethyl-2-(4-trifluoromethylphenyl)imidazole

→

1,5-dimethyl-4-formyl-2-(4-trifluoromethylphenyl)imidazole

収率 100.8%

溶媒

chloroform

反応条件

後処理

1. 1
   温度was refluxed for 24 hours
2. 2
   温度the mixture refluxed for a further 3 hours
3. 3
   温度The mixture was cooled
4. 4
   ろ過the solid material filtered off
5. 5
   洗浄washed with methylene chloride
6. 6
   その他The solvent was removed from the filtrate under reduced pressure

実験手順

A mixture of 1,5-dimethyl-4-hydroxymethyl-2-(4-trifluoromethylphenyl)imidazole (0.5 g) and manganese dioxide (2 g) in 20 ml of chloroform was refluxed for 24 hours. A further 2 g of manganese dioxide was added, and the mixture refluxed for a further 3 hours. The mixture was cooled, the solid material filtered off, and washed with methylene chloride. The solvent was removed from the filtrate under reduced pressure, to yield 0.5 g of 1,5-dimethyl-4-formyl-2-(4-trifluoromethylphenyl)imidazole, m.p. 144° C.

出典