反応 #5052

ord-38db96a21eb54cbaaeba038afad9b60c

反応方程式

O=[N+]([O-])c1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1
6-[4-(4-(5-aminoindol-3-yl)butyl)piperazino]-1,4-benzodioxane
O=[N+]([O-])c1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1
6-[4-(4-(5-nitroindol-3-yl)butyl)piperazino]-1,4-benzodioxane
CC(=O)Cl
acetyl chloride
CC(=O)Nc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1
6-[4-(4-(5-Acetamidoindol-3-yl)butyl)piperazino]-1,4-benzodioxane

溶媒

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他evaporated

実験手順

A solution of 4.21 g of 6-[4-(4-(5-aminoindol-3-yl)butyl)piperazino]-1,4-benzodioxane ("C") [obtainable as in Example 5] in 35 ml of THF is treated with a solution of 0.9 g of acetyl chloride in 10 ml of THF, and the mixture is stirred at 50° for 2 hours, evaporated and worked up in the conventional manner. 6-[4-(4-(5-Acetamidoindol-3-yl)butyl)piperazino]-1,4-benzodioxane is obtained.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05242925uspto-grants-1993_09