反応 #50498

反応方程式

Trimethylenediamine

5-chloromethyl-2-methylthiazole

sodium hydroxide

→

N-(2-methyl-5-thiazolylmethyl)trimethylenediamine

収率 89.9%

溶媒

acetonitrile

acetonitrile

反応条件

後処理

1. 1
   workup.ADDITIONAfter the addition
2. 2
   その他Subsequently, the volatile materials were removed at a bath temperature of less than 50° C. under 5 mmHg
3. 3
   その他The inorganic materials were removed from the residue by filtration

実験手順

Trimethylenediamine (37 g) was dissolved in 120 ml of acetonitrile, and a solution of 14.8 g of 5-chloromethyl-2-methylthiazole in 30 ml of acetonitrile was added dropwise at 10° to 15° C. After the addition, the mixture was stirred at 30° to 40° C. for a while, and then 8 g of a 50% aqueous solution of sodium hydroxide was added. Subsequently, the volatile materials were removed at a bath temperature of less than 50° C. under 5 mmHg. The inorganic materials were removed from the residue by filtration to give 16.7 g of N-(2-methyl-5-thiazolylmethyl)trimethylenediamine (purity about 90%) as a colorless oil.

出典