反応 #50475

反応方程式

methyl 4-chlorosalicylate

methyl 3-bromopropionate

potassium carbonate

→

desired material

収率 102.6%

4- Chloro-2-(2-methoxy-1-methyl-2-oxoethoxy)benzoic acid, methyl ester

収率 102.6%

溶媒

dimethyl formamide

water

反応条件

後処理

1. 1
   抽出The mixture was extracted with ether
2. 2
   洗浄the organics were washed with water
3. 3
   その他The organic layer was dried
4. 4
   その他evaporated

実験手順

A solution of methyl 4-chlorosalicylate (5.0 g) in dimethyl formamide (10 ml) was treated sequentially with methyl 3-bromopropionate (4.0 g) and potassium carbonate (6.0 g). The mixture was stirred at room temperature for 18 hrs and diluted with water. The mixture was extracted with ether and the organics were washed with water. The organic layer was dried and evaporated to give the desired material (6.7 g) as a low melting solid. NMR: 7.8 (d, 1H), 7.2 (m 1H), 6.9 (m, 1H), 4.8 (q, 1H), 3.9 (s, 3H), 3.8 (s, 3H), 1.7 (d, 3H).

出典