反応 #5045

反応方程式

Ethyl 4-pyridylacetate

hydrochloric acid

→

ethyl 4-piperidinylacetate

収率 162.3%

溶媒

ethanol

hydrogen

反応条件

後処理

1. 1
   ろ過the contents of the vessel were filtered
2. 2
   濃縮concentrated in vacuo

実験手順

16.5 g (0.1 mol) Ethyl 4-pyridylacetate, 8.4 mL (0.1 mol) 12N hydrochloric acid and 2.5 g platinum oxide were dissolved in absolute ethanol and hydrogenated at 40 psi hydrogen on a Parr shaker. After 1 hour, the contents of the vessel were filtered and concentrated in vacuo yielding 27.79 g of ethyl 4-piperidinylacetate.

出典