反応 #50407

反応方程式

6-(4-(2-(4-chlorobenzenesulphonylamino)ethyl)-phenyl)-6-(3-pyridyl)hex-5-enoic acid

methylene chloride

methyl iodide

→

6-(4-(2-(N-Methyl-4-chlorobenzenesulphonylamino)ethyl)phenyl)-6-(3-pyridyl)hex-5-enoic acid

溶媒

sodium hydroxide

反応条件

後処理

1. 1
   その他Then the organic phase is separated off
2. 2
   その他The product precipitated
3. 3
   その他is separated off
4. 4
   その他dried
5. 5
   その他evaporated down
6. 6
   その他Finally, the residue is chromatographed with ethylene chloride/methanol (97:3) over a silica gel column

実験手順

2.0 g of 6-(4-(2-(4-chlorobenzenesulphonylamino)ethyl)-phenyl)-6-(3-pyridyl)hex-5-enoic acid are stirred overnight in 10 ml of 4N sodium hydroxide solution, 100 ml of methylene chloride, 80 mg of benzyl trimethylammonium chloride and 0.85 g of methyl iodide. Then the organic phase is separated off and the aqueous phase is acidified to pH 5. The product precipitated is separated off and taken up in methylene chloride, dried and evaporated down. Finally, the residue is chromatographed with ethylene chloride/methanol (97:3) over a silica gel column.

出典