反応 #5040

反応方程式

HCl

nitrile

4-benzyloxybenzonitrile

triethylamine hydrochloride

sodium azide

→

5-(4-benzyloxyphenyl)tetrazole

収率 98.1%

溶媒

water

DMF

反応条件

後処理

1. 1
   温度under reflux for 18 hrs
2. 2
   その他The resulting white solid was collected
3. 3
   洗浄washed with water
4. 4
   その他dried at 60° C. in vacuo for 48 hrs

実験手順

A mixture of 285 g of the nitrile, 262.5 g triethylamine hydrochloride and 124 g of sodium azide in 1.5 L of DMF under nitrogen was stirred under reflux for 18 hrs. The reaction mixture was cooled to room temperature, poured into 4 L of cold water and acidified with 3N HCl. The resulting white solid was collected, washed with water and dried at 60° C. in vacuo for 48 hrs to give 337 g of 5-(4-benzyloxyphenyl)tetrazole.

出典