反応 #50293

反応方程式

water

potassium fluoride

18-crown-6

5-Chloro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline

→

Compound 41

5-Fluoro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline

溶媒

DMF

反応条件

後処理

1. 1
   温度This mixture was refluxed for 1.5 h
2. 2
   抽出The aqueous solution was extracted with ethyl acetate
3. 3
   その他the organic layer was separated
4. 4
   その他dried
5. 5
   その他the solvent removed m vacuo

実験手順

To a solution of 700 mg of potassium fluoride and 200 mg 18-crown-6 in 10 mL of DMF was added 5-Chloro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (200 mg). This mixture was refluxed for 1.5 h, cooled to room temperature and poured into water. The aqueous solution was extracted with ethyl acetate, the organic layer was separated and dried, and the solvent removed m vacuo to yield 5-Fluoro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (Compound 41), m.p. 154°-155° C.

出典