反応 #50238

反応方程式

1-benzylpiperazine

sulphuryl chloride

→

title compound

収率 89.0%

4-Benzyl-1-piperazinylsulphonyl chloride

収率 89.0%

溶媒

acetonitrile

acetonitrile

反応条件

後処理

1. 1
   温度the mixture heated
2. 2
   温度under reflux for 17 hours
3. 3
   温度cooled
4. 4
   その他The solvent was removed by evaporation under vacuum
5. 5
   その他the residue triturated with ether (20×50 ml)

実験手順

A solution of 1-benzylpiperazine (20.0 g, 0.114 mol) in acetonitrile (45 ml) was added to a solution of sulphuryl chloride (28 ml, 0.346 mol) in acetonitrile (50 ml) and the mixture heated under reflux for 17 hours, then cooled. The solvent was removed by evaporation under vacuum, then the residue triturated with ether (20×50 ml) to yield the title compound (27.8 g, 89%), which was used without further purification.

出典