反応 #5023

反応方程式

ethanol

N-acetyl-5-bromo-7-nitroindoline

hydrochloric acid

→

compound

収率 32.2%

N-acetyl-7-amino-5-bromoindoline

収率 32.2%

溶媒

water

反応条件

後処理

1. 1
   温度to refluxing for 5 hours with vigorous stirring
2. 2
   ろ過The reaction mixture was filtered by suction while hot
3. 3
   その他to remove insoluble matter
4. 4
   濃縮the filtrate thereof was concentrated
5. 5
   温度cooled

実験手順

To a mixed solution of ethanol (400 ml) and water (100 ml), were added N-acetyl-5-bromo-7-nitroindoline (133.1 g), iron powder (10 mesh; 75 g) and concentrated hydrochloric acid (5 ml), and the mixture was subjected to refluxing for 5 hours with vigorous stirring. The reaction mixture was filtered by suction while hot to remove insoluble matter, and then the filtrate thereof was concentrated and cooled on standing to give the intended compound 38.3 g (32.2%) as a brown needle crystal. M.P.: 154°-155° C.

出典