反応 #502148

反応方程式

2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

4,4-dimethylpiperidine

→

title compound

4-(4,4-Dimethylpiperidin-1-yl)-2-(3-chlorobenzyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

反応条件

実験手順

In analogy to the preparation of Example 1, 150 mg (0.51 mmol) of 2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 582 mg (5.14 mmol) of 4,4-dimethylpiperidine to give 96 mg (52% of theory) of the title compound.

出典