反応 #502146

ord-d55486cbbff1491a8299ee54761f3e57

反応方程式

CSc1nc(Cc2cccc(Cl)c2)[nH]c(=O)c1C#N
2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
NC1CCCC1
cyclopentylamine
N#Cc1c(NC2CCCC2)nc(Cc2cccc(Cl)c2)[nH]c1=O
title compound
N#Cc1c(NC2CCCC2)nc(Cc2cccc(Cl)c2)[nH]c1=O
2-(3-Chlorobenzyl)-4-(cyclopentylamino)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

In analogy to the preparation of Example 1, 100 mg (0.34 mmol) of 2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 292 mg (3.43 mmol) of cyclopentylamine to give 10 mg (9% of theory) of the title compound.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08088769B2uspto-grants-2012_01