反応 #502142

反応方程式

2-(2-methylbenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile

2-(4-piperidinyl)ethan-1-ol

→

title compound

4-[4-(2-Hydroxyethyl)-1-piperidinyl]-2-(2-methylbenzyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他the crude product is purified by preparative HPLC

実験手順

0.1 g (0.37 mmol) of 2-(2-methylbenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile is heated with 0.14 g (1.1 mmol) of 2-(4-piperidinyl)ethan-1-ol in 3 ml of acetonitrile at 90° C. under argon for five days. After cooling to room temperature, the crude product is purified by preparative HPLC. 13 mg (10% of theory) of the title compound are obtained as a colourless solid.

出典