反応 #502141

反応方程式

2-(3-methylbenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile

(S)-(+)-2-pyrrolidinemethanol

→

title compound

4-[(2S)-2-(Hydroxymethyl)-1-pyrrolidinyl]-2-(3-methylbenzyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他the crude product is purified by preparative HPLC

実験手順

0.1 g (0.37 mmol) of 2-(3-methylbenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile is heated with 0.11 g (1.1 mmol) of (S)-(+)-2-pyrrolidinemethanol in 3 ml of acetonitrile at 90° C. under argon for five days. After cooling to room temperature, the crude product is purified by preparative HPLC. 0.035 g (29% of theory) of the title compound is obtained as a colourless solid.

出典