反応 #502138

反応方程式

2-benzyl-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

piperidine

→

title compound

2-Benzyl-6-oxo-4-(1-piperidinyl)-1,6-dihydropyrimidine-5-carbonitrile

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他The resulting crude product is then purified by preparative HPLC

実験手順

43 mg (0.17 mmol) of 2-benzyl-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are suspended in 0.3 ml of acetonitrile and stirred with 42.7 mg (0.50 mmol) of piperidine at 85° C. for 16 h. The resulting crude product is then purified by preparative HPLC. 11 mg (22% of theory) of the title compound are obtained.

出典