反応 #502137

反応方程式

2-(3,4-dichlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

piperidine

→

title compound

2-(3,4-Dichlorobenzyl)-6-oxo-4-(1-piperidinyl)-1,6-dihydropyrimidine-5-carbonitrile

反応条件

後処理

1. 1
   その他After removal of the volatile constituents in vacuo
2. 2
   その他the residue is purified by preparative HPLC

実験手順

100 mg (0.34 mmol) of 2-(3,4-dichlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are stirred with 261 mg (3.07 mmol) of piperidine at 85° C. for 16 h. After removal of the volatile constituents in vacuo, the residue is purified by preparative HPLC. 42 mg (38% of theory) of the title compound are obtained.

出典