反応 #502111

反応方程式

((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methan-1-ol

triethylamine

tert-butylchlorodiphenylsilane

→

title compound

収率 106.2%

1-(((4S)-2,2-Dimethyl(1,3-dioxolan-4-yl))methoxy)-2,2-dimethyl-1,1-diphenyl-1-silapropane

収率 106.2%

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   洗浄the reaction mixture was washed with water, brine
2. 2
   乾燥dried over sodium sulfate
3. 3
   ろ過filtered
4. 4
   その他evaporated

実験手順

To a solution of ((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methan-1-ol (9 g, 68.6 mmol) in anhydrous dichloromethane (40 mL) were added triethylamine (11.2 mL), tert-butylchlorodiphenylsilane (19.8 g, 372 mmol), and N,N-dimethylaminopyridine (DMAP, 418 mg, 3.4 mmol) at room temperature under a nitrogen atmosphere. The reaction mixture was stirred at room temperature overnight. It was then diluted with additional dichloromethane and the reaction mixture was washed with water, brine, dried over sodium sulfate, filtered and evaporated to give the title compound (27 g) which was used in the next step without further purification.

出典