反応 #502106

反応方程式

1H-indazole-3-carboxylic acid

N,O-dimethylhydroxylamine hydrochloride

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

pyridine

→

compound

収率 69.1%

N-Methoxy-N-methyl-1H-indazole-3-carboxamide

収率 69.1%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   濃縮The mixture is concentrated
2. 2
   その他The yellow precipitate obtained
3. 3
   洗浄is washed with water
4. 4
   その他dried under reduced pressure

実験手順

In a round-bottomed flask, 4.0 g of 1H-indazole-3-carboxylic acid, 2.6 g of N,O-dimethylhydroxylamine hydrochloride, 9.4 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 8.4 ml of pyridine are placed in 120 ml of tetrahydrofuran. The mixture is stirred at ambient temperature for 20 h. The mixture is concentrated and the residue is taken up in water. The yellow precipitate obtained is washed with water and then dried under reduced pressure. 3.5 g of compound are obtained.

出典