反応 #502102

反応方程式

[4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol

hydrochloric acid

→

compound

[4-[(2-Quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol hydrochloride

溶媒

dichloromethane

isopropanol

methanol

反応条件

後処理

1. 1
   workup.ADDITIONare added to the filtrate
2. 2
   濃縮The reaction mixture is then concentrated under reduced pressure
3. 3
   ろ過The precipitate is recovered by filtration
4. 4
   その他oven-dried under reduced pressure

実験手順

100 mg of [4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol are suspended in dichloromethane and methanol. The solution is passed through a frit and 5.6 ml of a 0.1N solution of hydrochloric acid in isopropanol are added to the filtrate. The reaction mixture is then concentrated under reduced pressure and the residue is then taken up in diethyl ether. The precipitate is recovered by filtration and oven-dried under reduced pressure. 106 mg of compound are obtained.

出典