反応 #502099

反応方程式

2-(4-chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

hydrochloric acid

diethyl ether

→

compound

収率 199.0%

[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]boronic acid hydrochloride

収率 199.0%

溶媒

acetone

water

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture is stirred at ambient temperature for 24 h
2. 2
   濃縮The reaction mixture is then concentrated under reduced pressure
3. 3
   その他The solid obtained
4. 4
   ろ過recovered by filtration
5. 5
   その他dried in an oven under reduced pressure at 60° C

実験手順

3.60 g of 2-(4-chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine are dissolved in 112 ml of acetone and 56 ml of water; 101 ml of 1N hydrochloric acid are added thereto, dropwise and with stirring, and the mixture is stirred at ambient temperature for 24 h. The reaction mixture is then concentrated under reduced pressure. The solid obtained is titurated with diethyl ether and recovered by filtration, and then dried in an oven under reduced pressure at 60° C. 3.12 g of compound are obtained.

出典