反応 #502098

反応方程式

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine

2-bromo-1-(4-chlorophenyl)ethanone

sodium hydrogen carbonate

→

compound

収率 93.2%

2-(4-Chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

収率 93.2%

溶媒

n-propanol

反応条件

後処理

1. 1
   workup.WAITThe reaction mixture is left
2. 2
   温度to cool
3. 3
   濃縮concentrated under reduced pressure
4. 4
   その他the organic phase is then separated
5. 5
   乾燥dried over magnesium sulphate
6. 6
   その他the solvent is then evaporated off under reduced pressure

実験手順

2.5 g of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine and 2.65 g of 2-bromo-1-(4-chlorophenyl)ethanone in 76 ml of n-propanol are placed in a round-bottomed flask. 1.33 g of sodium hydrogen carbonate are added thereto. The mixture is heated at 80° C. for 16 h. The reaction mixture is left to cool and concentrated under reduced pressure. The residue is taken up between water and ethyl acetate, the organic phase is then separated by settling out and dried over magnesium sulphate, and the solvent is then evaporated off under reduced pressure. 3.75 g of compound are obtained.

出典