反応 #502097

反応方程式

sodium borohydride

5-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde

→

compound

収率 37.3%

{5-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-yl}methanol

収率 37.3%

溶媒

methanol

反応条件

後処理

1. 1
   その他the solvent is then evaporated off under reduced pressure
2. 2
   その他The organic phase is separated
3. 3
   乾燥dried over sodium sulphate
4. 4
   濃縮concentrated under reduced pressure

実験手順

122 mg of sodium borohydride are added, in small portions, to 104 mg of 5-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde dissolved in 20 ml of methanol. The mixture is subsequently stirred at ambient temperature for 2 hours, and the solvent is then evaporated off under reduced pressure. The residue is taken up between dichloromethane and water. The organic phase is separated, dried over sodium sulphate and concentrated under reduced pressure. 39 mg of compound are obtained.

出典