反応 #502054

反応方程式

chloroacetic acid methylester

3-nitrophenol

DMF

sodium carbonate

→

3-Nitrophenoxyacetic acid methylester

溶媒

water

反応条件

後処理

1. 1
   温度After being cooled down to 25° C. it
2. 2
   ろ過The resulting suspension is filtered off
3. 3
   洗浄The filter cake is washed with 300 g of water
4. 4
   その他dried in vacuum

実験手順

300 g of 3-nitrophenol are added to 800 ml of DMF. Then 240 g of sodium carbonate are added portionwise. Subsequently 270 g of chloroacetic acid methylester is added at 22° C. Then the mixture is stirred at 85° C. for six hours. After being cooled down to 25° C. it is given to 3 kg of water and 1 kg of ice. The resulting suspension is filtered off. The filter cake is washed with 300 g of water and dried in vacuum. Yield: 407 g.

出典