反応 #50196

反応方程式

methyl 6-benzoyloxy-2(RS)-bromo-hexanoate

potassium fluoride

acetamide

→

title compound ( f )

methyl 6-benzoyloxy-2(RS)-fluorohexanoate

methyl 6-benzoyloxyhexanoate

収率 58.3%

反応条件

後処理

1. 1
   その他The crude product obtained
2. 2
   workup.ADDITIONby treating in the conventional manner

実験手順

A mixture of methyl 6-benzoyloxy-2(RS)-bromo-hexanoate (e) (14.02 g), potassium fluoride (12.59 g) and acetamide (12.3 g) was stirred at 105° C. for 6 hours. The crude product obtained by treating in the conventional manner was subjected to silica gel chromatography to give the title compound (f) and methyl 6-benzoyloxyhexanoate (g) (3.11 g, yield: 29%).

出典