反応 #50181

反応方程式

4-methoxy-4-(3-methanesulfonyl-trans-prop-2-enyl)tetrahydropyran

sodium iodide

→

4-methoxy-4-(3-iodo-trans-propenyl)tetrahydropyran

収率 97.0%

溶媒

acetone

反応条件

後処理

1. 1
   その他The reaction was partitioned between ethyl acetate and brine
2. 2
   洗浄The organic layer was washed twice with brine
3. 3
   乾燥dried over MgSO4
4. 4
   ろ過filtered
5. 5
   濃縮concentrated in vacuo

実験手順

To a 0° C. solution in acetone of 4-methoxy-4-(3-methanesulfonyl-trans-prop-2-enyl)tetrahydropyran (505 mg, 2.02 mmol), prepared as in step 5 was added sodium iodide (605 mg, 4.03 mmol), and the reaction was stirred for 15 min. The reaction was partitioned between ethyl acetate and brine. The organic layer was washed twice with brine, dried over MgSO4, filtered and concentrated in vacuo to provide 4-methoxy-4-(3-iodo-trans-propenyl)tetrahydropyran (550 mg, 97%) as a dark yellow oil. The iodide was of sufficient purity to use without further purification.

出典