反応 #50167

反応方程式

(S)-2-pentanol

tetrahydrofuran

sodium hydride

bromoacetaldehyde diethylacetal

→

2-(4-methylbutyloxy)acetaldehyde diethylacetal

反応条件

後処理

1. 1
   温度the mixture was refluxed for 6 hours
2. 2
   濃縮After the reaction solution were concentrated
3. 3
   workup.ADDITIONwater and ether was added
4. 4
   workup.STIRRINGthe mixture was shaken
5. 5
   workup.ADDITIONfor mixing
6. 6
   その他The organic layer was collected
7. 7
   乾燥was dried with magnesium sulfate
8. 8
   その他to remove the solvent off
9. 9
   その他Purification

実験手順

35 g of (S)-2-pentanol was dissolved in tetrahydrofuran, and 16 g of 60% sodium hydride was added thereto. After stirring for 30 minutes, 80 g of bromoacetaldehyde diethylacetal was added thereto, and the mixture was refluxed for 6 hours. After the reaction solution were concentrated and water and ether was added thereto, the mixture was shaken for mixing. The organic layer was collected and was dried with magnesium sulfate to remove the solvent off. Purification was carried out by column chromatography to obtain 2-(4-methylbutyloxy)acetaldehyde diethylacetal (54).

出典