反応 #50165

反応方程式

tetrahydrofuran

compound ( 30 )

4-(1-methylbutyloxy)benzaldehyde

THF

butyllithium

bromide

→

1-(2-methoxyethenyl)-4-(1-methylbutyloxy)benzene

溶媒

hexane

反応条件

後処理

1. 1
   workup.ADDITIONwas added to a solution
2. 2
   workup.ADDITIONwas added
3. 3
   workup.STIRRINGstirring
4. 4
   workup.WAITwas continued for two hours
5. 5
   洗浄The reaction solution was washed with water
6. 6
   乾燥was dried over magnesium sulfate
7. 7
   濃縮was then concentrated
8. 8
   その他The residue was purified by column chromatography

実験手順

A solution containing butyllithium dissolved in hexane was added to a solution containing 120 g of methoxymethyltriphenylphosphoni bromide dissolved in tetrahydrofuran (THF), in an atmosphere of argon, and the mixture was stirred for one hour at room temperature. A solution of the compound (30) dissolved in THF was added thereto and stirring was continued for two hours. The reaction solution was washed with water, was dried over magnesium sulfate, and was then concentrated. The residue was purified by column chromatography to obtain 1-(2-methoxyethenyl)-4-(1-methylbutyloxy)benzene (31).

出典