反応 #50107

反応方程式

2e

1,3-dichloro-3-fluoro-7-oxabicyclo[4.1.0]heptane

alcohol

2-bromo-2,6-dichloro-6-fluorocyclohexanol

sodium hydroxide

→

epoxide

収率 80.0%

1-bromo-3-chloro-3-fluoro-7-oxabicyclo[4.1.0]heptane

収率 80.0%

溶媒

water

反応条件

後処理

1. 1
   その他Reaction time
2. 2
   その他1 h 15 min
3. 3
   抽出ether extraction (4×7 cm3)

実験手順

The same procedure was followed as for the production of 2e in Example 17: it was performed with 0.20 g (0.75 mmol) of alcohol 1i, 3 cm3 of water and 0.12 g (3 mmol) of sodium hydroxide. Reaction time: 1 h 15 min; ether extraction (4×7 cm3). After treatment, 0.15 g of epoxide 2g were obtained (macrobore GC purity>97.5%), having a yield of 80%.

出典