反応 #50101

反応方程式

alcohol

2,2,6-trichloro-6-fluorocyclohexanol

acetone

→

alcohol

収率 32.0%

2,2,6-trichloro-6-fluorocyclohexanol

収率 32.0%

diol

2,2,6-trichloro-6-fluoro-1,1-cyclohexane-diol

反応条件

後処理

1. 1
   その他fitted with a condenser and with magnetic stirring
2. 2
   workup.ADDITION5 cm3 of the Jones reactant were introduced gently
3. 3
   温度the reaction mixture was then heated to 45°-50° C. for 16 h
4. 4
   workup.ADDITION(1 cm3 of Jones reactant having been added after 4 h and 2 cm3 after 9 h of reaction)
5. 5
   その他At the end of reaction the Jones reactant
6. 6
   その他was destroyed with 10 cm3 of isopropanol
7. 7
   workup.ADDITIONthe mixture was diluted with 10 cm3 of water
8. 8
   抽出extracted with dichloromethane
9. 9
   乾燥dried over magnesium sulfate
10. 10
    その他the solvents were evaporated off
11. 11
    その他purified by flash chromatography

実験手順

0.5 g (2.26 mmol) of alcohol 1b in solution in 3 cm3 of acetone were introduced into a 10-cm3 round bottom flask fitted with a condenser and with magnetic stirring. 5 cm3 of the Jones reactant were introduced gently; the reaction was highly exothermic; the reaction mixture was then heated to 45°-50° C. for 16 h (1 cm3 of Jones reactant having been added after 4 h and 2 cm3 after 9 h of reaction). At the end of reaction the Jones reactant was destroyed with 10 cm3 of isopropanol, the mixture was diluted with 10 cm3 of water, extracted with dichloromethane and dried over magnesium sulfate, and the solvents were evaporated off. The material was incorporated onto silica and purified by flash chromatography. 0.16 g of starting alcohol 1b (32%) and 0.30 g of pure diol 3a were isolated, that was a 56% yield of compound 3a (Yld based on the unrecovered alcohol 1b=85%).

出典